I figured I was destined to a life time of popping blisters until I discovered the Injinji Tetratsok. Unlike convention socks that cram your toes together causing friction and eventually blisters, Injinji toe socks separate your little piggies. Individual anatomical toe sleeves form a thin anti-blister membrane between toes to eliminate skin-against-skin friction. I have been wearing the Injinji's for 2 years now and haven't have a single blister even when doing runs of up to six hours, and with very wet feet.
They come is different styles from micro-mini to crew to match your individual preference. They are also made with various materials such as CoolMax, NuWool and NuBamboo, an Eco Series collection made primarily of natural, organic, and sustainable fibers. If blisters have been a problem for you, you may want to take the Injinji toe socks out for a run. You've got nothing to lose but your blisters!